Endocrine Abstracts

Objectives: To analyse the outcome of 100 consecutive patients treated for thyrotoxicosis by total thyroidectomy, and compare the efficacy of this treatment modality to I131 therapy and thionamide therapy.Design: Data collected prospectively from a tertiary referral multidisciplinary thyroid clinic on 100 consecutive patients operated on for thyrotoxicosis by one thyroid surgeon. Patient demographics, reasons for selection of surgical treatmen...

BackgroundChronic fatigue syndrome (CFS) is a debilitating condition with high morbidity and associated reduced quality of life. There are data suggesting neuro-endocrine axis involvement in CFS including disturbance in hypothalamic-pituitary-adrenal axis, growth hormone axis, opioidergic system and interactions with 5-Hydroxy Tryptamine (5-HT) system. Studies with selective 5-HT-releasing agents, using prolactin or cortisol responses to stimulation, fou...

Calcium and Vitamin D deficiency is a common cause of falls and fracture and supplementation with 1 g of calcium and 800 IU of vitamin D is commonly recommended.However, the serum level of 25 OHD that defines deficiency is controversial, and the 25 OHD level required to normalise serum parathyroid hormone (PTH)-in the presence of normal calcium- is often used. In this study we set out to explore how effective is 1 g of calcium and 800 IU of vitamin D in ...

Introduction: Impaired glucose regulation (IGR) is usually defined as impaired fasting glucose (IFG, fasting plasma glucose (FPG) is between 6.1 to 6.9 mmol/L) and/or impaired glucose tolerance (IGT, 2 hour postprandial glucose (PPG) is 7.8 to 11 mmol/L). More recently, a haemoglobin A1c (HbA1c) ≥ 42 but <47 mmol/mol has been suggested to indicate an increased diabetes risk. Women with polycystic ovary syndrome (PCOS) are strongly associated with insulin resistance a...

Background: Vitamin D insufficiency is very common in general population and in patients with primary hyperparathyroidism (PHPT). Measurement of serum 25OHD (25hydroxy-vitamin D) is currently the best available test to assess vitamin D adequacy. However, it has a significant seasonal variation, and is difficult to define a serum 25OHD level that is sufficient for bone health, although a serum 25OHD above 50 nmol/l has been suggested.Previous studies conf...

Background: Postprandial hypertriglyceridaemia is an independent risk factor for cardiovascular diseases. An acute rise of insulin in the fed state suppresses hormone-sensitive lipase to inhibit free fatty acids (FFAs) mobilisation from adipose tissue, and up-regulates lipoprotein lipase to increase FFAs influx to adipose tissue from chylomicrons, that is blunted in insulin resistant states. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and cardiovascu...